Does Spermicidal Condoms Work Better Than Condoms Without Spermicidal? Condoms MyAlly Health Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex. Protection works best when you use it right. Follow these simple #Condom do's and don'ts to take care of yourself and your partners.