Frontiers Inhalation of nicotine containing electronic cigarette vapor exacerbates the features of COPD by inducing ferroptosis in ENaC overexpressing mice Smoking poses severe dangers to lung health, including: 1. Lung Cancer Smoking is the leading cause of lung cancer, increasing the risk of developing this deadly disease. 2. Chronic Obstructive Pulmonary Disease ( E cigs: What You Need to Know if You Care for Patients with COPD Challenges in COPD Will chronic e cigarette use cause lung disease? Thoracic and Sleep Group Queensland